Seattle’s Week 1 inactive list reshapes the Seahawks’ game plan against San Francisco, with Bobo, Dareke Young and Uchenna Nwosu among seven SEA players out. The 49ers also rolled seven, trimming depth at multiple spots. Expect increased opportunities for Seattle’s top receivers and for linebackers stepping into larger roles, as both teams adjust to missing contributors in a considered Week 1 matchup.

Key Seahawks absences include Bobo and Young at wide receiver and Nwosu on the edge, while the 49ers sit several depth players to open the door for others. In fantasy terms, the biggest shifts come from who absorbs the extra targets and snaps on SEA’s offense and who gains reps in SF’s depth chart, potentially altering streamer and DFS value in a marquee Week 1 battle.

Seattle's Week 1 build is thinning at wide receiver. Bobo is sidelined by concussion, Tory Horton ankle, Cody White shoulder, and Dareke Young hamstring, with Horton practicing fully later in the week. Uchenna Nwosu is ramping up but not yet ready. Seattle has just six WR on the active roster, leaving depth questions for the 49ers defense. Jaxon Smith-Njigba and Cooper Kupp are noted as the players not on the initial injury report.

The Seahawks could lean on practice-squad options Ricky White III, Courtney Jackson, and Tyrone Broden if needed. Tyrice Knight’s knee absence is notable but he looks set to play, a big boost for the defense. Injury updates roll out Thursday and Friday ahead of Sunday’s 1:05 p.m. kickoff at Lumen Field.

Seattle’s 20-7 preseason loss to Green Bay showcased a messy night but also several bright spots for the Seahawks’ depth chart. Patrick O’Connell led Seattle with seven tackles and flashed on special teams, while Ty Okada delivered a diving first-quarter interception that could bolster a roster push. UDFA standouts Cody White, Connor O’Toole, Jared Ivey, and JR Singleton impressed with flashes of edge and run-game disruption, hinting at possible 53-man or practice-squad spots. Milroe showed raw upside and costly miscues, underscoring the coaching staff’s pace to expand his playbook in 2026. On the flip side, the O-line reserves were overwhelmed, Jake Bobo’s concussion raised depth-chart questions, and the Seahawks could pursue veteran help or more waiver-wire options. Jacardia Wright’s big 61-yard run gave Seattle a glimmer of backfield potential, while Shaquill Griffin’s return highlighted a shaky corner depth. The final takeaway: roster cuts loom, UDFA shine will drive waiver conversations, and special-teams coaching will face scrutiny as Seattle pivots toward the real games.

Seattle's preseason health update brings cautious optimism. Jake Bobo sustained a concussion after a punt-return collision with Tyler Hall, but walked off under his own power; Hall’s leg injury isn’t as bad as it looked, and Christian Haynes’ pec issue is not as serious as feared. Seattle escaped the night without any massive injuries, keeping the door open for Week 1 decisions.

These updates matter for fantasy rosters and depth charts: Bobo’s timeline could shift receiver targets and punt-return roles, Hall’s availability shapes the secondary, and Haynes’ status could influence roster moves as camp resumes. Overall, Seattle dodged major injury scares and will reassess next week with practice continuing.